Adenosine A2AReceptor Inactivation Increases Survival in Polymicrobial Sepsis

Adenosine A2A receptor inactivation increases survival in polymicrobial sepsis.

The mechanisms governing the impairment of bacterial clearance and immune function in sepsis are not known. Adenosine levels are elevated during tissue hypoxia and damage associated with sepsis. Adenosine has strong immunosuppressive effects, many of which are mediated by A(2A) receptors (A(2A)R) expressed on immune cells. We examined whether A(2A)R are involved in the regulation of immune func...

Effects of pharmacological inactivation of adenosine 2A receptors in a murine model of polymicrobial sepsis

Sepsis is a worldwide health problem with an enormous economic burden and devastatingly high mortality rate. The pathophysiology and immune dysfunctions that occur during sepsis remain largely unknown, severely limiting current treatment options for sepsis. Both the innate and adaptive parts of the immune system are known to be involved in the dysfunctions that occur during sepsis. Over the las...

Sepsis Survival in Mice Phagocytosis and Improves Polymicrobial Macrophage-Mediated Bacterial A2B Adenosine Receptor Blockade Enhances

Chronic Viral Infection and Exacerbates Polymicrobial Sepsis Increases Susceptibility

Patients who survive sepsis display suppressed immune functions, often manifested as an increased susceptibility to secondary infections. Recently, using a cecal-ligation and puncture (CLP) model of sepsis, we showed that sepsis induces substantial and long-lasting changes in the available naive CD8 + T cell repertoire affecting the capacity of the host to respond to newly encountered acute inf...

Adoptive transfer of in vitro-stimulated CD4+CD25+ regulatory T cells increases bacterial clearance and improves survival in polymicrobial sepsis.

Regulatory CD4(+)CD25(+) T cells (Tregs) suppress autoimmune and inflammatory diseases through mechanisms that are only partly understood. Previous studies suggest that Tregs can suppress bacterially triggered intestinal inflammation and respond to LPS through TLRs with enhanced suppressive activity. In this study, we have used murine cecal ligation and puncture as a model of polymicrobial seps...